Superantigens: Molecular Basis for Their Role in Human Diseases
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چکیده
منابع مشابه
Superantigens: Molecular Basis for Their Role in Human Diseases
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The ability of superantigens to activate large numbers of T cells suggests that they may play a role in the course of autoimmune disorders. Data from several animal models of autoimmune disorders including experimental allergic encephalomyelitis and collagen induced arthritis supports this hypothesis. Administration of bacterial superantigens can induce an exacerbation of the autoimmune process...
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Introduction: The exact cause of most autoimmune diseases is still unknown; however, several factors play a role in causing or exacerbating autoimmune reactions. In addition to environmental factors such as bacterial, parasitic, fungal and viral infections, factors such as genetic characteristics and lifestyle are also included. Infections caused by viruses usually trigger a strong immune respo...
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Superantigens are a group of bacterial and viral proteins that are characterized by their capacity to stimulate a large number of T cells. They bind directly to the major histocompatibility complex class II molecule on the antigen-presenting cell and cross-link the antigen-presenting cell with T cells expressing certain T-cell receptors, leading to polyclonal T-cell activation. They have been s...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2008
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1405.080089